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The FROG Serene Cartridge Kit - 3 Bromine + 1 Mineral (01-14-3856) for Frog In-Line and Floating Frog Systems Spa Frog Mineral Sanitizers are the only mineral systems for spas that work with low levels of bromine for the highest water quality. Mineral and bromine spa care. Cartridges work in the frog floating and in-line systems.